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Search Results for " p21 activated kinases "

13

Compounds

Cat No. Product Name Synonyms Targets
T6839 FRAX1036 PAK
FRAX-1036 is a effective and selective PAK1 inhibitor.
T16367 NVS-PAK1-1 PAK
NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).
T6014 FRAX597 PAK
FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
T16429 GNE 2861 PAK
GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.
T11342L G-5555 PAK
G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).
T6840 FRAX486 PAK
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
T6546 IPA-3 IPA3,IPA 3 PAK
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
T0646 5-Aminosalicylic Acid Mesalazine,5-ASA,Mesalamine NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Endogenous Metabolite , PAK , PPAR
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
T11826 LCH-7749944 GNF-PF-2356 Apoptosis , PAK
LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w...
T2539 Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720 TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T6626 PF-3758309 PF-309,PF-03758309,PF 3758309 Apoptosis , PAK
PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.
T4230 PF-3758309 hydrochloride PF-03758309 hydrochloride Apoptosis , PAK
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...
T7939 Fingolimod FTY-720A,FTY-720 S1P Receptor , PAK , LPL Receptor
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
TargetMol